THE A34 at Alderley Edge is closed following a collision.
Cheshire Police estimate the road will open again in one hour.
The collision happened just after 1pm in Melrose Way, and involved two vehicles.
Fire engines from Wilmslow, Poynton and Congleton attended.
A Cheshire Fire and Rescue spokesman said: "One man was trapped in an overturned vehicle, a second man was trapped in a separate vehicle.
"The road was closed in both directions by police while the crews removed the casualties. Both men were taken to hospital by North West Ambulance Service.
"Crews were at the scene for approximately 50 minutes."
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